Publications

BOADA, J.N.; BORGES, R.; BOBET, J.M. and FERIA, M.M. (1982)
Action of methanephrine on the responses to catecholamines in the isolated rat atria
Arch. Farmacol. Toxicol. 8, 7-11.

RODRIGUEZ, S.A.; FERIA, M.M.; BORGES, R. and BOADA, J.N. (1984)
Effects of anaesthesia on rat respiration: a study in decerebrated, decerebrated-anaesthetized and intact brain preparation
Rev. Esp. Fisiol. 40, 53-62.

BOADA, J.N.; NAVARRO, E.; RODRIGUEZ, R.; BORGES, R.; ALARCO, B. and MARTIN, P. (1984)
Cardiac and extracardiac activity of ethanolic extract of leaves of Isoplexis canariensis
Planta Med. 4, 307-309.

SALA, F.; FONTERIZ, R.I.; BORGES, R. and GARCIA, A.G. (1986)
Inactivation of potassium-evoked adrenomedullary catecholamine release in the presence of calcium, strontium and BAY-K-8644
FEBS Lett. 196, 34-38.

BORGES, R.; FERIA, M.; DIAZ, E.; RODRIGUEZ-MENDEZ, S.A. and BOADA, J.N. (1986)
Effect of ethanol on neuromuscular function in rats. Its interaction with alcuronium
Gen. Pharmacol. 17, 569-572.

BORGES, R.; SALA, F. and GARCIA, A.G. (1986)
Continuous monitoring of catecholamine release from perfused cat adrenals
J. Neurosc. Meth. 16, 289-300.

GARCIA, A.G.; ARTALEJO, C.R.; BORGES, R.; REIG, J.A. and SALA, F. (1986)
Pharmacological propierties of chromaffin cell calcium channel. In: Biophysics of the pancreatic ß-Cell;
Ed. by Atwater, Rojas and Soria. Plenum Publ Co, Bethesda; USA. 139-157.

BORGES, R.; BALLESTA, J.J. and GARCIA, A.G. (1987)
M2 muscarinoceptor-associated ionophore at the cat adrenal medulla
Biochem. Biophys. Res. Com. 144, 965-972.

CARDENAS, A.M.; MONTIEL, C.; ESTEBAN, C.; BORGES, R. and GARCIA, A.G. (1988)
Secretion from adrenaline- and noradrenaline-storing adrenomedullary cells is regulated by a common dihydropyridine-sensitive calcium channel
Brain Res. 456, 364-366.

BORGES, R.; CARTER, D.V.; GRAFENSTEIN, H.V.; HALLIDAY, J. and KNIGHT, D.E. (1989)
Activation of sodium channels is not essential for endothelin induced vasoconstriction
Pflügers Arch. 413, 313-315.

BORGES, R.; CARTER, D.V.; GRAFENSTEIN, H.V.; HALLIDAY, J. and KNIGHT, D.E. (1989)
Ionic requirements of endothelin response in aorta and portal vein
Circ. Res. 65, 265-271.

BORGES, R.; GRAFENSTEIN, H.V. and KNIGHT, D.E. (1989)
Tissue selectivity of endothelin
Eur. J. Pharm. 165, 223-230.

BALLESTA, J.J.; BORGES, R.; GARCIA, A.G. and HIDALGO, M.J. (1989)
Secretory and radioligand binding studies on muscarinic receptors in bovine and feline chromaffin cells
J. Physiol. 418, 411-426.

ALAMO, L.; GARCIA, A.G. and BORGES, R. (1991)
Electrically-evoked catecholamine release from cats adrenals. Role of cholinergic receptors.
Biochem. Pharmacol. 42, 973-978.

LOPEZ, M.G.; ABAD, F.; SANCHO, C.; DE PASCUAL, R.; BORGES, R.; MAROTO, R.; DIXON, W. and GARCIA, A.G. (1991)
Membrane-mediated effects of the steroid 17--estradiol on adrenal catecholamine release.
J. Pharmacol. Exp. Ther. 259, 259-285.

GRAFENSTEIN, H.V.; BORGES, R. and KNIGHT, D.E. (1992)
The effects of botulinum toxin type D on the triggered and constitutive exocytosis/endocytosis cycles in cultures of bovine adrenomedullary cells.
FEBS Lett. 298, 118-122.

CANDENAS, M.L.; NORTE, M.; GONZALEZ, R.; ARTECHE, E.; FERNANDEZ, J.J.; BORGES, R.; BOADA, J.N.; ADVENIER, C. and MARTIN, J.D. (1992)
Inhibitory and contractile effects of okadaic acid on rat uterine muscle.
Eur. J. Pharmacol. 219, 473-476.

BORGES, R. (1993)
Ionic mechanisms involved in the secretory effects of histamine in the rat adrenal medulla.
Eur. J. Pharmacol. 241, 189-194.

BORGES, R. (1994)
Histamine H1 receptor activation mediates the preferential release of adrenaline in the rat adrenal gland.
Life Sci. 54, 631-640.

GARCIA-LOPEZ, M.; ALBILLOS, A.; DE LA FUENTE, M.T.; BORGES, R.; GANDIA, L.; CARBONE, E.; GARCIA, A.G. and ARTALEJO, A.R. (1994)
Localized L-type calcium channels control exocytosis in cat chromaffin cells.
Pflügers Archiv. 427, 348-354.

GANDIA, L.; BORGES, R.; ALBILLOS, A. and GARCIA, A.G. (1995)
Multiple calcium channels subtypes are present in rat chromaffin cells.
Pflügers Archiv. 430, 55-63.

FINNEGAN, J.M.; BORGES, R. and WIGHTMAN, R.M. (1996)
Intracellular calcium and secretion from individual adrenal chromaffin cells. A comparison between the rat and bovine.
Neuroscience 71, 833-843.

GANDIA, L.; VILLARROYA, M.; LARA, B.; OLMOS, V.; GILABERT, J.A.; GARCIA-LOPEZ, M.; MARTINEZ-SIERRA, R.; BORGES, R. and GARCIA, A.G. (1996)
Otilonium, a potent blocker of neuronal nAChR.
Brit. J. Pharmacol. 117, 463-470.

GANDIA, L.; GARCIA-LOPEZ, M.; VILLARROYA, M.; GILABERT, J.A.; CARDENAS, A.M.; GARCIA, A.G. and BORGES, R. (1996)
Blocking effect of otilonium on calcium-channels and secretion in rat chromaffin cells.
Eur. J. Pharmacol. 298, 199-206.

SCHROEDER, T.J.; BORGES, R.; FINNEGAN, J.M.; AMATORE, C.; PIHEL, K. and WIGHTMAN, R.M. (1996)
Temporally resolved, independent stages of individual exocytotic secretion events.
Biophys. J. 70, 1061-1068. A

PIHEL, K.; TRAVIS, E.R.; BORGES, R. and WIGHTMAN, R.M. (1996)
Exocytotic release from individual granules exhibits similar properties al mast cells and chromaffin cells.
Biophys. J. 71, 1633-1641.

BORGES, R.; SCHROEDER, T.J. and WIGHTMAN, R.M (1996)
Resolución temporal del fenómeno exocitótico en la célula cromafín. Hipótesis quimiosmótica.
In: Neurociencia y Computación Neuronal, Ed. By Suárez-Araujo and Regidor
Eds. Univ. Las Palmas de Gran Canaria; Spain. 167-174.

ALVAREZ, C.; LORENZO, C. and BORGES, R. (1997)
Interaction between G protein-operated receptors eliciting secretion in rat adrenals: A possible role of protein kinase C.
Biochem. Pharmacol 53, 317-325.

GONZALEZ-MORA, J.L.; BORGES, R. and MAS, M. (1997)
Monitoring molecules in Neuroscience.
Ed. Universidad de La Laguna. ISBN. 84-7756-445-0

BORGES, R. (1997)
The rat adrenal gland in the study of the control of catecholamine secretion.
Semin. Cell. Dev. Biol. 8, 113-120.

BORGES, R.; TRAVIS, E.R.; HOCHSTETLER, S.E. and WIGHTMAN, R.M. (1997)
Effects of external osmotic pressure on vesicular secretion from bovine medullary cells.
J. Biol. Chem. 272, 8325-8331.

BORGES, R. (1998)
The pharmacoperiodic table.
Trends Pharm. Sci. 19, (Inserted poster).

SANTANA, F.; MICHELENA, P.; JAEN, R.; GARCIA, AG. and BORGES, R. (1999)
Calcium channel subtypes and exocytosis in chromaffin cells: a different view from the intact rat adrenal.
Naunyn Schmiedeberg Arc. Pharmacol. 360, 33-37.

SANCHEZ, J.L.; BRIOSO, M.A.; SEGURA, F. and BORGES, R. (1999)
A new way for the analysis of exocytosis.
In: Medical informatics Europe ’99.
Eds. P. Kokol et al. IOS Press. 400-405.

MACHADO, J.D.; SEGURA, F.; BRIOSO, M.A. and BORGES, R. (2000)
Nitric oxide modulates a late step of exocytosis.
J. Biol. Chem. 275, 20274-20279.

BORGES, R.; VILLAMANDOS, G. and JAÉN, R. (2000)
Warning! perfusion syringes may not be inert.
Eur. J. Clin. Invest. 30, 653.

BORGES, R.; MACHADO, J.D.; ALONSO, C.; BRIOSO, M.A. and GOMEZ, J.F. (2000)
Functional role of chromogranins and intragranular matrix in the last phase of exocytosis.
In. Chromogranins. Functional and clinical aspects. K.B. Helle & D. Aunis Editors.
Advances in Experimental Medicine and Biology, 482, 67-82.
Kluwer Academic/Plenum Publishers, New York – London, ISBN. 0-306-46446-2.

SEGURA, F.; BRIOSO, M.A.; GOMEZ, JF; MACHADO, J.D. and BORGES, R. (2000)
Automatic analysis for amperometrical recordings of exocytosis.
J. Neurosci. Meth. 103, 151-156.

BORGES, R.; JAÉN, R.; FREIRE, F.; GOMEZ, J.F.; VILLAFRUELA, C. and YANES, E. (2001)
Morphological and functional characterization of beige mouse adrenomedullary secretory vesicles.
Cell Tiss. Res. 304, 159-164.

MACHADO, J.D.; MORALES, M.A.; GOMEZ, J.F. and BORGES, R. (2001)
cAMP modulates the exocytotic kinetics and increases the quantal size in chromaffin cells.
Mol. Pharmacol. 60, 514-520.

BORGES, R. and MACHADO, J.D. (2002)
Chromaffin cell: from basic to clinical research in the new millennium.
Trends Pharm. Sci. 23, 53-55.

MACHADO, J.D.; ALONSO, C.; MORALES, M.A.; GÓMEZ, J.F. and BORGES, R. (2002)
Nongenomic regulation of the kinetics of exocytosis by estrogens.
J. Pharmacol. Exp. Ther. 301, 631-637.

BORGES, R.; MACHADO, J.D.; BETANCOR, G. and CAMACHO, M. (2002)
Pharmacological regulation of the late steps of exocytosis.
Ann. NY Acad. Sci. 971, 184-192.

MACHADO, J.D.; ALONSO, C.; MORALES, M.A. and BORGES, R. (2002)
A novel non-genomic action of estrogens: the regulation of exocytotic kinetics.
Ann. NY Acad. Sci. 971, 284-286.

GÓMEZ, J.F.; BRIOSO, M.A.; MACHADO, J.D.; SÁNCHEZ, J.L. and, BORGES, R. (2002)
New approaches for analysis of amperometrical recordings.
Ann. NY Acad. Sci. 971, 647-654.

MACHADO, J.D.; GÓMEZ, J.F.; BETANCOR, G.; CAMACHO, M.; BRIOSO, M.A. and BORGES, R. (2002)
Hydralazine reduces the quantal size of secretory events by displacement of catecholamines from adrenomedullary chromaffin secretory vesicles.
Cir. Res. 91, 830-836.

CAMACHO, M.; MONTESINOS, M.S.; MACHADO, J.D. y BORGES, R. (2003)
La exocitosis como mecanismo de comunicación neuronal. Una visión desde la célula cromafín.
Rev. Neurol. 36, 355-360.

ÑECO, P.; GINER, D.; VINIEGRA, S.; BORGES, R.; VILLARROEL, A. and GUTIÉRREZ, L.M. (2004)
New roles of myosin II during vesicle transport and fusion in chromaffin cells.
J. Biol. Chem. 279, 27450-27457.

BORGES, R.; DELGADO, G. and DÍAZ, J. (2004)
New insights about the functional role of chromogranins in the latest steps of exocytosis
Curr. Med. Chem. 4, 187-193.

BORGES, R. and GANDÍA, L. (2004)
Cell Biology of the Chromaffin Cell.
Instituto Teófilo Hernando. ISBN 84-688-7007-2
http://isccb12.webs.ull.es/TheBook.htm

BORGES, R.; DÍAZ, J.; CAMACHO, M and MACHADO, J.D. (2005)
A Simple Way to Build a Grinder for Carbon Fibre Electrodes for Amperometry or Voltammetry.
Pflügers. Arc. 450, 280-282

CAMACHO, M.; MACHADO, J.D.; MONTESINOS, M.S.; CRIADO, M. and BORGES, R. (2006)
Intragranular pH Rapidly Modulates Exocytosis in Adrenal Chromaffin Cells.
J. Neurochem. 96, 324-334.

LINDAU, M. and BORGES, R. (2006)
Kavli Workshop in Pucón. Advanced Techniques to Study Single Vesicle Exocytosis
Ann. NY Acad. Sci.
www.nyas.org/kavli

ARDILES, A.O.; MARIPILLAN, J.; LAGOS, V.L.; TORO, R.; MORA, I.G.; VILLARROEL, L.; ALES, E.; BORGES, R. and CARDENAS, A.M. (2006).
A rapid exocytosis mode in chromaffin cells with a neuronal phenotype
J. Neurochem. 99, 29-41.

GARCÍA, A.G.; GARCÍA DE DIEGO, A.M.; GANDÍA, L.; BORGES, R. and GARCÍA-SANCHO, J. (2006)
Calcium signalling and exocytosis in chromaffin cells.
Physiol. Rev. 86, 1093-1131.

CARABELLI, V.; MARCANTONI, A.; COMUNANZA, V.; DE LUCA, A.; DIAZ, J.; BORGES, R. and CARBONE, E. (2007)
Chronic hypoxia up-regulates 1H T-type channels and low-threshold catecholamine secretion in rat chromaffin cells.
J. Physiol (London) 584, 149-165.

MACHADO, J.D.; MONTESINOS, M.S. and BORGES, R. (2008)
Good practices in single cell amperometry.
Methods Mol. Biol. 440, 297-313.

BORGES, R.; CARBONE, E.; NISTRI, A. and VERKHRASTSKY, A. (2008)
Physiology of the Chromaffin Cell.
Acta Physiol. 192, 143-144.

BORGES, R.; CAMACHO, M. and GILLIS, K.D. (2008)
Measuring secretion in chromaffin cells using electrophysiological and electrochemical methods.
Acta Physiol. 192, 145-163.

DÍAZ-FLORES, L.; GUTIÉRREZ, R.; VARELA, H.; VALLADARES, F.; ALVAREZ-ARGÜELLES, H. and BORGES, R. (2008)
Histogenesis and morphofunctional characteristics of chromaffin cells.
Acta Physiol 192, 173-184.

MONTESINOS, M.S.; MACHADO, J.D.; CAMACHO, M.; DÍAZ, J.; MORALES, Y.G.; ALVAREZ DE LA ROSA, D.; CARMONA, E.; CASTAÑEYRA, A.; VIVEROS, O.H.; O’CONNOR, D.T.; MAHATA, S.T. and BORGES, R. (2008)
The crucial role of chromogranins in storage and exocytosis revealed using chromaffin cells from chromogranin a null mouse.
J. Neurosci. 28, 3350-3358.

CAMACHO, M.; MACHADO, J.D.; ÁLVAREZ, J and BORGES, R. (2008)
Intravesicular calcium release mediates the motion and exocytosis of secretory organelles: A study with adrenal chromaffin cells.
J. Biol. Chem. 283, 22383-22389.

CAMACHO, M.; MACHADO, J.D.; ÁLVAREZ, J and BORGES, R. (2009)
On the role of intravesicular calcium in the motion and exocytosis of secretory organelles.
Commun. & Integrat. Biol. 2, 71-73.

DIAZ-VERA, J.; MORALES, Y.G.; HERNANDEZ-FERNAUD, J.; CAMACHO, M.; MONTESINOS, M.; CALEGARI, F. HUTTNER, W.; BORGES, R. and MACHADO, J.D. (2010)
Chromogranin B gene ablation reduces the catecholamine cargo and decelerates exocytosis in chromaffin secretory vesicles.
J. Neurosci. 30, 950-957.

MONTESINOS, M.S.; CAMACHO, M.; MACHADO, J.D.; VIVEROS, O.H.; BELTRÁN B. and BORGES, R. (2010)
The quantal secretion of catecholamines is impaired by the accumulation of -blockers into sympathetic secretory vesicles
Br. J. Pharmacol. 159, 1548-1556 .

BORGES, R.; DÍAZ-VERA, J.; DOMÍNGUEZ, N.; ARNAU, M.R. and MACHADO, J.D. (2010)
Chromogranins as regulators of exocytosis
J. Neurochem. 114, 335–343.

MACHADO, J.D.; DÍAZ-VERA, J.; DOMÍNGUEZ, N.; ÁLVAREZ, C.M.; PARDO, M.R. and BORGES, R. (2010)
Chromogranins A and B as regulators of vesicle cargo and exocytosis
Cell Mol Neurobiol. 30, 1181-1187.

BORGES, R.; PEREDA, D.; BELTRÁN, B.; PRUNELL, M.; RODRÍGUEZ, M. and MACHADO, J.D. (2010)
Intravesicular factors controlling exocytosis in chromaffin cells
Cell Mol Neurobiol. 30, 1159-1164.

BELTRÁN, B.; CARRILLO, R.; MARTÍN, T.; MARTÍN, V.S.; MACHADO, J.D. and BORGES, R. (2011)
Fluorescent -blockers as tools for the study presynaptic mechanisms of neurosecretion
Pharmaceuticals 4, 713-725.

MILLA, J.; MONTESINOS, M.S.; MACHADO, J.D.; BORGES, R.; ALONSO, E.; MORENO-ORTEGA, A.J.; CANO-ABAD, M.A.; GARCÍA, A.G. and RUIZ-NUÑO, A. (2011)
Ouabain enhances exocytosis through the regulation of calcium handling by the endoplasmic reticulum of chromaffin cells.
Cell Calcium 50, 332-342.

DOMÍNGUEZ, N; RODRÍGUEZ, M.; MACHADO, J.D. and BORGES, R. (2012)
Preparation and culture of adrenal chromaffin cells
Methods Mol Biol. 846, 223-234.

DÍAZ-VERA, J.; CAMACHO, M.; MACHADO, J.D.; DOMÍNGUEZ, N.; MONTESINOS, M.S.; HERNÁNDEZ-FERNAUD, J.R.; LUJÁN, R. and BORGES, R. (2012)
Chromogranins A and B are key proteins in amine accumulation but the catecholamine secretory pathway is conserved without them.
FASEB J. 26, 430-438.

BORGES, R.; DOMÍNGUEZ, N.; ESTÉVEZ-HERRERA, J.; PEREDA, D. and MACHADO, J.D. (2012)
Vesicular Ca2+ mediates granule motion and exocytosis.
Cell Calcium 51, 338–341.

DOMÍNGUEZ, N.; ESTÉVEZ-HERRERA, J.; PARDO, M.R.; PEREDA, D. MACHADO, J.D. and BORGES, R. (2012)
Functional roles of chromogranins in the exocytotic process.
J. Mol Neurosci. 48, 317–322.

PONSATI, B.; CARREÑO, C.; CURTO-REYES, V.; VALENZUELA, B.; DUART, M.J.; VAN DEN NEST, W.; CAULI, O.; BELTRAN, B.; FERNANDEZ, J.; BORSINI, F.; CAPRIOLI, A.; DI SERIO, S.; VERETCHY, M.; BAAMONDE, A.; MENENDEZ, L.; BARROS, F.; DE LA PEÑA, P.; BORGES, R.; FELIPO, V.; PLANELLS-CASES, R. and FERRER-MONTIEL, A. (2012)
An inhibitor of neuronal exocytosis (DD04107) displays long-lasting in vivo activity against chronic inflammatory and neuropathic pain.
J. Pharmacol Exp. Ther. 341, 634-45.

BORGES, R. (2013)
The ATP or the Natural History of neurotransmission.
Purinergic Sig. 9, 5-6.

BORGES, R.; DOMINGUEZ, N.; SMITH, C.B.; BANDYOPADHYAY, G.K.; O’CONNOR, D.T.; MAHATA, S.K. and BARTOLOMUCCI, A. (2013)
Granins and catecholamines: Functional interaction in chromaffin cells and adipose tissue.
Adv. Pharmacol. 68, 93-113.

ESTEVEZ-HERRERA, J.; RODRIGUEZ-PARDO, M.; DOMINGUEZ, N.; MACHADO, J.D. and BORGES, R. (2013)
On the role of chromogranins in the secretory pathway.
BioMol. Concepts 4, 605-609.

BORGES, R. (2014)
We need a global system to help identify new uses for existing drugs
Br. Med. J. 348, g1806.

BALSERA, B.; MULET, J.; FERNÁNDEZ-CARVAJAL, A.; DE LA TORRE MARTINEZ, R.; FERRER-MONTIEL, A.; HERNÁNDEZ-JIMÉNEZ, J.G.; ESTÉVEZ-HERRERA, J.; BORGES, R.; FREITAS, A.E.; LÓPEZ, M.G.; GARCÍA-LÓPEZ, M.T.; GONZÁLEZ-MUÑIZ, R.; PÉREZ DE VEGA, M.J.; VALOR, L.M.; SVOBODOVÁ, L.; SALA, S.; SALA, F. and CRIADO, M. (2014)
Chalcones as positive allosteric modulators of 7 nicotinic acetylcholine receptors: A new target for a privileged structure.
Eur. J. Med. Chem. 86, 724-739.

DOMÍNGUEZ, N.; ESTEVEZ-HERRERA, J.; BORGES, R. and MACHADO, J.D. (2014)
The interaction between chromogranin A and catecholamines governs exocytosis.
FASEB J. 28, 4657-4667.

PEREDA, D.; PARDO, M.R.; MORALES, Y.; DOMINGUEZ, N.; ARNAU, M.R. and BORGES, R (2015)
Mice lacking chromogranins exhibit increased aggressive and depression-like behaviour
Behav. Brain Res. 278, 98-106.

DÍAZ-MARTÍN, D.; HERNÁNDEZ-JIMÉNEZ, J.G.; RODRÍGUEZ-VALIDO, M. and BORGES, R. (2015)
Measuring the contractile response of isolated tissue using an image sensor.
Sensors 15, 9179-9188.